Down syndrome and Alzheimers

Down Syndrome and Alzheimer’s Disease

The APP protein, which is the product of a gene on human chromosome 21, contributes to the degeneration of specific neuronal circuits important for learning and memory. This same neuronal degeneration is also a characteristic feature of Alzheimer’s disease. Dr. Mobley and his colleagues at UCSD are continuing to investigate the genetic, molecular and cellular mechanisms that lead to learning and memory difficulties, including association with Alzheimer’s disease and to test small molecules and compounds that would reduce the level of the APP protein in mice and lead to the improvements in cognition and halt neurodegeneration of affected neuronal circuits.

Courtesy:DSRTF

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